HPE expanded its NVIDIA AI Computing by HPE portfolio with new ProLiant Compute servers powered by NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs and enhanced capabilities in HPE Private Cloud AI. The updates target enterprise generative, agentic, and physical AI workloads, offering customers accelerated compute in both new 2U and 4U form factors. The DL385 Gen11 model supports up to two GPUs, while the DL380a Gen12 supports up to eight and will begin shipping in September.
The new generation of HPE Private Cloud AI integrates the latest NVIDIA Nemotron models for agentic AI, the Cosmos Reason vision-language model for robotics, and NVIDIA’s Blueprint for Video Search and Summarization (VSS 2.4). These additions aim to streamline development of AI agents capable of extracting insights from large-scale video datasets. The platform offers secure, scalable, air-gapped management with multi-tenancy support and enables faster deployment of NVIDIA NIM microservices.
Through its ongoing partnership with NVIDIA, HPE is positioning its hardware and AI software stack as a turnkey enterprise AI factory. This includes high-performance inferencing for robotics, industrial automation, visual computing, and simulation workloads, while maintaining enterprise-grade security with quantum-resistant firmware signing and centralized lifecycle automation.
- New ProLiant DL385 Gen11 server: 2U form factor, up to 2 NVIDIA RTX PRO 6000 Blackwell GPUs, air-cooled.
- ProLiant DL380a Gen12: 4U, up to 8 GPUs, shipping in September 2025.
- Expanded HPE Private Cloud AI with NVIDIA Nemotron, Cosmos Reason, and VSS 2.4 blueprints.
- Enterprise-grade security with HPE iLO 7 Silicon Root of Trust.
- Lifecycle automation via HPE Compute Ops Management reduces management time by up to 75%.
- Target workloads: generative AI, agentic AI, robotics, industrial automation, visual computing, simulation, 3D modeling, digital twins.
“HPE is committed to empowering enterprises with the tools they need to succeed in the age of AI,” said Cheri Williams, senior vice president and general manager for private cloud and flex solutions at HPE. “Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads.”
🌐 Why it Matters
This expansion strengthens HPE’s positioning in the high-performance AI infrastructure market by pairing its enterprise hardware expertise with NVIDIA’s latest Blackwell architecture and AI model ecosystem. By offering both scalable GPU server configurations and turnkey AI factory software, HPE is targeting the growing demand for on-premises, secure AI development platforms—critical for enterprises balancing innovation with data control.
